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Article

Screening of the COL2A1 mutation in idiopathic osteonecrosis of the femoral head.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Apr 2017

Sakamoto Yuma, Yamamoto Takuaki, Miyake Noriko, Matsumoto Naomichi, Iida Aritoshi, Nakashima Yasuharu, Iwamoto Yukihide, Ikegawa Shiro

Abstract excerpt

Idiopathic osteonecrosis of the femoral head (idiopathic ONFH) is an ischemic disorder resulting in necrosis of the subchondral bone of the femoral head. COL2A1 mutations, including c.3508G>A, have been reported to be involved in its etiology. However, the etiological role of COL2A1 mutations in idiopathic ONFH remains controversial, because the pathology of idiopathic ONFH is ischemic necrosis, not epiphyseal...

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PMID: 27183340
DOI: 10.1002/jor.23300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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