Article
A systematic evaluation of short tandem repeats in lipid candidate genes: riding on the SNP-wave.
PloS one - 1 Jan 2014
Lamina Claudia, Haun Margot, Coassin Stefan, Kloss-Brandstätter Anita, Gieger Christian, Peters Annette, Grallert Harald, Strauch Konstantin, Meitinger Thomas, Kedenko Lyudmyla, Paulweber Bernhard, Kronenberg Florian
Abstract excerpt
Structural genetic variants as short tandem repeats (STRs) are not targeted in SNP-based association studies and thus, their possible association signals are missed. We systematically searched for STRs in gene regions known to contribute to total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride levels in two independent studies (KORA F4, n = 2553 and SAPHIR, n = 1648), resulting in 16 STRs that were...
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