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Article

Hepatitis E genotype 4 virus from feces of monkeys infected experimentally can be cultured in PLC/PRF/5 cells and upregulate host interferon-inducible genes.

Journal of medical virology - 1 Oct 2014

Zhang Feng, Qi Ying, Harrison Tim J, Luo Baobin, Zhou Yan, Li Xiuhua, Song Aijing, Huang Weijin, Wang Youchun

Abstract excerpt

The understanding of the interaction between hepatitis E virus (HEV) and its host cells has been impeded greatly by the absence of a cell culture system. In this study, an efficient cultivation method was developed in PLC/PRF/5 cells for HEV genotype 4 from the feces of monkeys infected experimentally. Compared to minimal essential medium (MEM), mixed Dulbecco's Modified Eagle's Medium (DMEM)/M199 improved the...

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Source

Identifiers

PMID: 25042677
DOI: 10.1002/jmv.24014

Genes

CMPK2
IFI27
IFI6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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