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Article

Optimized Hepatitis E Virus (HEV) Culture and its Application to Measurements of HEV Infectivity.

Viruses - 24 Jan 2020

Capelli Nicolas, Dubois Martine, Pucelle Mélanie, Da Silva Isabelle, Lhomme Sébastien, Abravanel Florence, Chapuy-Regaud Sabine, Izopet Jacques

Abstract excerpt

Hepatitis E virus (HEV) is a major concern in public health worldwide. Infections with HEV genotypes 3, 4, or 7 can lead to chronic hepatitis while genotype 1 infections can trigger severe hepatitis in pregnant women. Infections with all genotypes can worsen chronic liver diseases. As virions are lipid-associated in blood and naked in feces, efficient methods of propagating HEV clinical strains in vitro and...

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Identifiers

PMID: 31991673
DOI: 10.3390/v12020139
PMCID: PMC7077187

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