Article
Micro-evolution of the hepatitis B virus genome in hepatitis B e-antigen-positive carriers: comparison of genotypes B and C at various immune stages.
Journal of gastroenterology and hepatology - 1 Jan 2015
Liu Chun-Jen, Chen Ting-Chih, Chen Pei-Jer, Wang Hurng-Yi, Tseng Tai-Chung, Cheng Huei-Ru, Liu Chen-Hua, Chen Ding-Shinn, Kao Jia-Horng
Abstract excerpt
BACKGROUND AND AIM: Patients with hepatitis B virus (HBV) genotype B infection experience hepatitis B e-antigen (HBeAg) seroconversion at an earlier stage than do patients with genotype C infection. Therefore, this study investigated whether the differential phenotypes are related to HBV genomic evolution. METHODS: Thirty-three HBeAg-positive patients with a mean follow-up of 3.1 years were enrolled: 16 at the...
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