Article
ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity.
Journal of biomedical science - 19 Jul 2014
Chou He-Yen, Lin Yu-Hung, Shiu Guan-Lin, Tang Hsiang-Yu, Cheng Mei-Ling, Shiao Ming-Shi, Pai Li-Mei
Abstract excerpt
BACKGROUND: Methionine, an essential amino acid, is required for protein synthesis and normal cell metabolism. The transmethylation pathway and methionine salvage pathway (MTA cycle) are two major pathways regulating methionine metabolism. Recently, methionine has been reported to play a key role in Drosophila fecundity. RESULTS: Here, we revealed that the MTA cycle plays a crucial role in Drosophila fecundity...
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