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Article

Absence of BRCA/FMR1 correlations in women with ovarian cancers.

PloS one - 1 Jan 2014

Gleicher Norbert, McAlpine Jessica N, Gilks C Blake, Kushnir Vitaly A, Lee Ho-Joon, Wu Yan-Guang, Lazzaroni-Tealdi Emanuela, Barad David H

Abstract excerpt

Previously reported findings in Austrian BRCA1/2 mutation carriers suggested a possible dependency of embryos with BRCA1/2 mutations on so-called low alleles of the fragile X mental retardation 1 (FMR1) gene, characterized by less than 26 CGG repeats (CGG(n<26)). The hypothesis arose from a study reporting highly statistically significant enrichment of low FMR1 alleles, significantly exceeding low allele...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25036526
DOI: 10.1371/journal.pone.0102370
PMCID: PMC4103842

Genes

BRCA1
FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of BRCA/FMR1 correlations in women with ovarian cancers.PMID 25036526Read ↗

BRCA1/2 mutations appear embryo-lethal unless rescued by low (CGG n<26) FMR1 sub-genotypes: explanation for the "BRCA paradox"?Semantic proximity Read ↗

FMR1 low sub-genotype does not rescue BRCA1/2-mutated human embryos and does not explain primary ovarian insufficiency among BRCA1/2-carriers.Semantic proximity Read ↗

Diminished ovarian reserve is not observed in infertility patients with high normal CGG repeats on the fragile X mental retardation 1 (FMR1) geneSemantic proximity Read ↗

Early decline in functional ovarian reserve in young women with low (CGGn < 26) FMR1 gene alleles.Semantic proximity Read ↗

Utilizing FMR1 gene mutations as predictors of treatment success in human in vitro fertilization.Semantic proximity Read ↗

FMR1 CGG allele length in Israeli BRCA1/BRCA2 mutation carriers and the general population display distinct distribution patterns.Semantic proximity Read ↗

Ovarian dysfunction and FMR1 alleles in a large Italian family with POF and FRAXA disorders: case report.Semantic proximity Read ↗

Impact of FMR1 Pre-Mutation Status on Blastocyst Development in Patients Undergoing Pre-Implantation Genetic Diagnosis.Semantic proximity Read ↗

Premature ovarian failure and FMR1 gene mutations: an update.Semantic proximity Read ↗

Variable expression of the Fragile X Mental Retardation 1 (FMR1) gene in patients with premature ovarian failure syndrome is not dependent on number of (CGG)n triplets in exon 1.Semantic proximity Read ↗

The FMR1 gene as regulator of ovarian recruitment and ovarian reserve.Semantic proximity Read ↗

Influence of intermediate and uninterrupted FMR1 CGG expansions in premature ovarian failure manifestation.Semantic proximity Read ↗

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