Article
Variable expression of the Fragile X Mental Retardation 1 (FMR1) gene in patients with premature ovarian failure syndrome is not dependent on number of (CGG)n triplets in exon 1.
Human reproduction (Oxford, England) - 1 May 2011
Schuettler J, Peng Z, Zimmer J, Sinn P, von Hagens C, Strowitzki T, Vogt P H
Abstract excerpt
BACKGROUND: Increased expression of the Fragile X Mental Retardation 1 (FMR1) gene in blood cells has been claimed to be associated with variable (CGG)(n) triplet numbers in the 5' untranslated region of this gene. Increased CGG triplet numbers, including that of the so-called premutation range (n= 55-200), were shown to have a risk of <26% to impair ovarian reserve leading to primary ovarian insufficiency and...
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