Article
Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis.
Circulation - 4 Sept 2018
Oldoni Federico, Baldassarre Damiano, Castelnuovo Samuela, Ossoli Alice, Amato Mauro, van Capelleveen Julian, Hovingh G Kees, De Groot Eric, Bochem Andrea, Simonelli Sara, Barbieri Simone, Veglia Fabrizio, Franceschini Guido, Kuivenhoven Jan Albert, Holleboom Adriaan G, Calabresi Laura
Abstract excerpt
BACKGROUND: Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear because mutations in LCAT causing fish-eye disease (FED) or familial LCAT deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with...
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