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Article

(Epi)Genetic analyses of age-related macular degeneration: case-control and discordant twin studies.

Human heredity - 1 Jan 2014

Hutchinson John N, Fagerness Jes, Kirby Andrew, Reynolds Robyn, Zak Alex, Gimelbrant Alexander, Plenge Robert, Daly Mark, Chess Andrew, Seddon Johanna M

Abstract excerpt

BACKGROUND/AIMS: Phenotypic discordance in monozygotic (MZ) twin pairs can have an epigenetic or genetic basis. Although age-related macular degeneration (AMD) has a strong genetic component, few studies have addressed its epigenetic basis. METHODS: Using SNP arrays, we evaluated differences in copy number variation (CNV) and allele-specific methylation (ASM) patterns (via methyl-sensitive restriction enzyme...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25033836
DOI: 10.1159/000362814
PMCID: PMC6476332

Genes

CFB
CFH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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