Article
Age-related macular degeneration with discordant late stage phenotypes in monozygotic twins.
Ophthalmic genetics - 1 Nov 2011
Keilhauer Claudia N, Fritsche Lars G, Weber Bernhard H F
Abstract excerpt
PURPOSE: Age-related macular degeneration (AMD) is a complex disease caused by genetic and environmental factors. Monozygotic twins with late stage AMD provide an opportunity to evaluate the role of environmental factors on a genetically uniform background. METHODS: Monozygosity was determined in four twin pairs by genotyping 15 highly polymorphic tetranucleotide repeat markers. Clinically, the monozygotic twin...
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