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Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits.

Molecular psychiatry - 1 Apr 2014

Wong C C Y, Meaburn E L, Ronald A, Price T S, Jeffries A R, Schalkwyk L C, Plomin R, Mill J

Abstract excerpt

Autism spectrum disorder (ASD) defines a group of common, complex neurodevelopmental disorders. Although the aetiology of ASD has a strong genetic component, there is considerable monozygotic (MZ) twin discordance indicating a role for non-genetic factors. Because MZ twins share an identical DNA sequence, disease-discordant MZ twin pairs provide an ideal model for examining the contribution of environmentally...

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Child Development Disorders, Pervasive
CpG Islands
Diseases in Twins
Epigenomics
Mental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psychiatric Status Rating Scales

Twins, Monozygotic

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PMID: 23608919
DOI: 10.1038/mp.2013.41
PMCID: PMC3906213

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