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Pathobiology of Paget's Disease of Bone

1 Jan 2014

Abstract excerpt

Paget's disease of bone is characterized by highly localized areas of increased bone resorption accompanied by exuberant, but aberrant new bone formation with the primary cellular abnormality in osteoclasts. Paget's disease provides an important paradigm for understanding the molecular mechanisms regulating both osteoclast formation and osteoclast-induced osteoblast activity. Both genetic and environmental...

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PMID: 25025000
DOI: 10.11005/jbm.2014.21.2.85

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