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Article

Mannose-binding lectin and ficolin-2 do not influence humoral immune response to hepatitis B vaccine.

Vaccine - 20 Aug 2014

Osthoff Michael, Irungu Elizabeth, Ngure Kenneth, Mugo Nelly, Thomas Katherine K, Baeten Jared M, Eisen Damon P

Abstract excerpt

BACKGROUND: Host genetics appear to be an important factor in the failure to generate a protective immune response after hepatitis B (HBV) vaccination. Mannose-binding lectin (MBL) and ficolin-2 (FCN2), two pattern recognition receptors of the lectin pathway of complement, influence the clinical outcome of HBV, and MBL deficiency has been shown to augment the humoral response to HBV vaccination in several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25024112
DOI: 10.1016/j.vaccine.2014.06.023
PMCID: PMC4374143

Genes

FCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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