Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Baculovirus-Mediated miRNA Regulation to Suppress Hepatocellular Carcinoma Tumorigenicity and Metastasis

15 Jul 2014

Abstract excerpt

MicroRNA 122 (miR-122) is a tumor suppressor for hepatocellular carcinoma (HCC) but is lowly expressed in HCC cells. MiR-151 is aberrantly overexpressed in HCC cells and promotes HCC metastasis yet its roles on HCC tumorigenicity are unknown. To combat HCC tumorigenicity/metastasis, we developed Sleeping Beauty (SB)-based hybrid baculovirus (BV) vectors that expressed (i) miR-122 precursors (pre-miR-122), (ii)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver physiology and pathology
Share to MicroRNA in disease regulation
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25023326
DOI: 10.1038/mt.2014.126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Baculovirus-Mediated miRNA Regulation to Suppress Hepatocellular Carcinoma Tumorigenicity and MetastasisPMID 25023326Read ↗

miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loopSemantic proximity Read ↗

Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.Semantic proximity Read ↗

Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activitySemantic proximity Read ↗

Circulating microRNA-122a as a diagnostic marker for hepatocellular carcinomaSemantic proximity Read ↗

The liver‐specific microRNA‐122*, the complementary strand of microRNA‐122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitrySemantic proximity Read ↗

MicroRNA-152 targets ADAM17 to suppress NSCLC progression.Semantic proximity Read ↗

MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.Semantic proximity Read ↗

Ultrasound-mediated delivery of miRNA-122 and anti-miRNA-21 therapeutically immunomodulates murine hepatocellular carcinoma in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.