Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia

11 Jul 2014

Abstract excerpt

The ecotropic viral integration site-1 gene (EVI1) encodes a zinc finger protein that functions as a transcriptional regulator of hematopoietic stem cell self-renewal and long-term multilineage repopulating activity. The mixed lineage leukemia gene (MLL) rearrangements [i.e. t(11q23)] occur at high frequency in pediatric acute myeloid leukemia (AML) patients with EVI1 overexpression, 3 and EVI1 is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25015941
DOI: 10.3324/haematol.2014.107128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemiaPMID 25015941Read ↗

EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemiaSemantic proximity Read ↗

High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AMLSemantic proximity Read ↗

[EVI1 expression, clinical and cytogenetical characteristics in 447 patients with acute myeloid leukemia].Semantic proximity Read ↗

Clinical Significance of Dynamic Monitoring of EVI1 Gene Expression in Pediatric Acute Myeloid LeukemiaSemantic proximity Read ↗

High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patientsSemantic proximity Read ↗

High <i> <scp>EVI</scp> 1 </i> expression is associated with <i> <scp>MLL</scp> </i> rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's oncology groupSemantic proximity Read ↗

Low EVI1 expression at diagnosis predicted poor outcomes in pediatric Ph-negative B cell precursor acute lymphoblastic leukemia patientsSemantic proximity Read ↗

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.Semantic proximity Read ↗

Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemiaSemantic proximity Read ↗

EVI1-mediated Programming of Normal and Malignant HematopoiesisSemantic proximity Read ↗

<i>TET1</i> plays an essential oncogenic role in <i>MLL</i> -rearranged leukemiaSemantic proximity Read ↗

Evi1 forms a bridge between the epigenetic machinery and signaling pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.