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Article

Association of ABCB1 polymorphisms with the antiemetic efficacy of granisetron plus dexamethasone in breast cancer patients.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Tsuji Daiki, Kim Yong-Il, Nakamichi Hidenori, Daimon Takashi, Suwa Kaori, Iwabe Yutaro, Hayashi Hideki, Inoue Kazuyuki, Yoshida Masayuki, Itoh Kunihiko

Abstract excerpt

Resistance to antiemetic treatment with 5-hydroxytryptamine 3 receptor antagonists is a problem, with 20-30% of patients showing unsatisfactory responses. Efflux transport by P-glycoprotein, encoded by the ATP-binding cassette ABCB1 gene in the blood-brain barrier, has been the suggested resistance mechanism. We evaluated the association between the antiemetic efficacy of granisetron plus dexamethasone and ABCB1...

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Source

Identifiers

PMID: 23358260
DOI: 10.2133/dmpk.dmpk-12-rg-084

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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