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Article

Regioselective hydroxylation of omeprazole enantiomers by bacterial CYP102A1 mutants.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2014

Ryu Sang Hoon, Park Bo-Yeon, Kim So-Young, Park Sun-Ha, Jung Hyun-Jin, Park Min, Park Ki Deok, Ahn Taeho, Kang Hyung-Sik, Yun Chul-Ho

Abstract excerpt

A large set of Bacillus megaterium CYP102A1 mutants are known to metabolize various drugs to form human metabolites. Omeprazole (OMP), a proton pump inhibitor, has been widely used as an acid inhibitory agent for the treatment of gastric acid hypersecretion disorders. It is primarily metabolized by human CYP2C19 and CYP3A4 to 5'-OH OMP and a sulfone product, respectively. It was recently reported that several...

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PMID: 25008345
DOI: 10.1124/dmd.114.058636

Genes

OMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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