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Article

Regioselective hydroxylation of omeprazole enantiomers by bacterial CYP102A1 mutants.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2014

Ryu Sang Hoon, Park Bo-Yeon, Kim So-Young, Park Sun-Ha, Jung Hyun-Jin, Park Min, Park Ki Deok, Ahn Taeho, Kang Hyung-Sik, Yun Chul-Ho

Abstract excerpt

A large set of Bacillus megaterium CYP102A1 mutants are known to metabolize various drugs to form human metabolites. Omeprazole (OMP), a proton pump inhibitor, has been widely used as an acid inhibitory agent for the treatment of gastric acid hypersecretion disorders. It is primarily metabolized...

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Source

Identifiers

PMID: 25008345
DOI: 10.1124/dmd.114.058636

Genes

OMP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25008345-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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