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Article

CDK4 inhibition and doxorubicin mediate breast cancer cell apoptosis through Smad3 and survivin.

Cancer biology & therapy - 1 Oct 2014

Tarasewicz Elizabeth, Hamdan Randala, Straehla Joelle, Hardy Ashley, Nunez Omar, Zelivianski Stanislav, Dokic Danijela, Jeruss Jacqueline S

Abstract excerpt

Cyclin D1/CDK4 activity is upregulated in up to 50% of breast cancers and CDK4-mediated phosphorylation negatively regulates the TGFβ superfamily member Smad3. We sought to determine if CDK4 inhibition and doxorubicin chemotherapy could impact Smad3-mediated cell/colony growth and apoptosis in breast cancer cells. Parental and cyclin D1-overexpressing MCF7 cells were treated with CDK4 inhibitor, doxorubicin, or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25006666
DOI: 10.4161/cbt.29693
PMCID: PMC4130723

Genes

CDK4
DIABLO
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CDK4 inhibition and doxorubicin mediate breast cancer cell apoptosis through Smad3 and survivin.PMID 25006666Read ↗

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