Article

Chidamide combined with doxorubicin induced p53-driven cell cycle arrest and cell apoptosis reverse multidrug resistance of breast cancer

2020-09-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>The multidrug-resistant (MDR) phenotype is usually accompanied by an abnormal expression of histone deacetylase (HDAC). Given that HDAC is vital in chromatin remodeling and epigenetics, inhibiting the role of HDAC has become an important approach for tumor treatment. However, the effect of HDAC inhibitors on MDR breast cancer has not been elucidated. This study...

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Literature Corpus work: 334804dc-edd9-59ae-9331-7b7d767b6c71
DOI: 10.21203/rs.3.rs-67615/v2

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