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Article

Cyclin D1 Overexpression and Response to Bortezomib Treatment in a Breast Cancer Model

5 Sept 2006

Abstract excerpt

BACKGROUND: Cyclin D1 is frequently overexpressed in breast cancer, and its overexpression is, surprisingly, associated with improved survival. One potential mechanism for this association involves signal transducer and activator of transcription 3 (STAT3). METHODS: Cyclin D1 and STAT3 expression were assessed in human tumors using microarray analysis and in breast cancer cell lines HBL100, T47D, MCF7,...

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PMID: 16954476
DOI: 10.1093/jnci/djj334

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