Methylomic Changes of Autophagy-Related Genes by Legionella Effector Lpg2936 in Infected Macrophages

Abstract excerpt

Legionella pneumophila is a Gram-negative bacteria that infects human respiratory tract causing Legionaries disease; a severe form of pneumonia. Recently, rising evidence indicated the ability of Legionella to regulate host defense via its type 4 secretion system including hundreds effectors which promote intracellular bacterial replication. Host defense against such invaders includes the autophagic machinery...

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