Article
Clinical and molecular epidemiology of neonatal leukemia in Brazil.
Leukemia & lymphoma - 1 Apr 2015
Moura Suellen Valadares, Andrade Francianne, Magalhães Isis Q, Costa Imaruí, Silva Denise Bousfield, D'Andrea Maria Lydia, Pinheiro Vitória P, Lee Maria Lucia M, Werneck Fernando, Emerenciano Mariana, Pombo-de-Oliveira Maria S
Abstract excerpt
The clinical and molecular findings of 77 cases of neonatal leukemia (NL) and 380 of infant leukemia (IL) were selected to distinguish features between NL and IL. Somatic gene mutations associated with acute leukemia including FLT3, RAS and PTPN11 were revisited. There were 42 cases of congenital leukemia associated with Down syndrome (DS) and 39 of these cases presented features of acute myeloid leukemia...
Topics
- Brazil
- Cytogenetic Analysis
- DNA Mutational Analysis
- Female
- Follow-Up Studies
- GATA1 Transcription Factor
- Histone-Lysine N-Methyltransferase
- Humans
- In Situ Hybridization, Fluorescence
- Infant
- Infant, Newborn
- Kaplan-Meier Estimate