Article
Abl Kinases Regulate Actin Comet Tail Elongation via an N-WASP-Dependent Pathway
30 Sept 2005
Abstract excerpt
Microbial pathogens have evolved diverse strategies to modulate the host cell cytoskeleton to achieve a productive infection and have proven instrumental for unraveling the molecular machinery that regulates actin polymerization. Here we uncover a mechanism for Shigella flexneri-induced actin comet tail elongation that links Abl family kinases to N-WASP-dependent actin polymerization. We show that the Abl kinases...
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