Article
Clinical characteristics and risk factors for survival in affected offspring of von Hippel-Lindau disease patients.
Journal of medical genetics - 1 Oct 2022
Zhang Kenan, Qiu Jianhui, Yang Wuping, Ma Kaifang, Li Lei, Xie Haibiao, Xu Yawei, Gong Yanqing, Zhou Jingcheng, Cai Lin, Gong Kan
Abstract excerpt
BACKGROUND: Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic tumour syndrome with poor prognosis. The clinical manifestation was found to be more serious in affected offspring of patients with VHL disease, but the risk factors and survival for them have never been reported before. We aimed to explore how these patients were influenced by genetic and clinical factors. METHODS: In this retrospective...
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