Article
Clinical and mutation analysis of four Chinese families with von Hippel-Lindau disease.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 May 2013
Chen J, Geng W, Zhao Y, Zhao H, Wang G, Huang F, Liu F, Geng X
Abstract excerpt
OBJECTIVE: von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome predisposed to the development of tumors in a variety of body organs. The major etiopathogenesis of VHL is a mutation of the VHL tumor-suppressor gene on the short arm of chromosome 3 (3p25-26). We report on the clinical and molecular features of four Chinese kindreds with VHL disease. MATERIALS AND METHODS: The VHL gene was screened for...
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