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Article

Analysis of single-nucleotide polymorphisms (SNPs) in human CYP3A4 and CYP3A5 genes: potential implications for the metabolism of HIV drugs.

BMC medical genetics - 2 Jul 2014

Berno Giulia, Zaccarelli Mauro, Gori Caterina, Tempestilli Massimo, Antinori Andrea, Perno Carlo Federico, Pucillo Leopoldo Paolo, D'Arrigo Roberta

Abstract excerpt

BACKGROUND: Drug metabolism via the cytochrome P450 (CYP450) system has emerged as an important determinant in the occurrence of several drug interactions (adverse drug reactions, reduced pharmacological effect, drug toxicities). In particular, CYP3A4 and CYP3A5 (interacting with more than 60% of licensed drugs) exhibit the most individual variations of gene expression, mostly caused by single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24986243
DOI: 10.1186/1471-2350-15-76
PMCID: PMC4083125

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