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Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer

20 Jun 2014

Abstract excerpt

Malignant proliferation is the fundamental trait of tumor cells. The initiation of DNA replication represents a key process for cell proliferation, and has a marked impact on tumorigenesis and progression. Here we report that Sine oculis homeobox homolog 1 (SIX1) functions as a master regulator in DNA replication of cervical cancer cells. The expression of SIX1 was induced by the E7 oncoprotein of human...

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Identifiers

PMID: 24970368
DOI: 10.3892/ijo.2014.2510

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