Article
Screening for EGFR mutations in lung cancer, a report from India.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2011
Sahoo Rashmita, Harini V Vidya, Babu V Chitti, Patil Okaly Geeta V, Rao Smitha, Nargund Ashwini, Venkataswamy E, Rao Raghavendra, Kumar B S Ajai
Abstract excerpt
Epidermal growth factor receptor (EGFR) is one of the targeted molecular markers in many cancers including the lung malignancy. Genetic modifications such as deletions, insertions and Single Nucleotide Polymorphisms in the tyrosine kinase (TK) domain of EGFR is a common feature observed in most lung cancers. Gefitinib and erlotinib are commonly available therapeutic drugs which act as specific inhibitors for the...
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