Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa.

Brain : a journal of neurology - 1 Mar 2006

Ibáñez Pablo, Lesage Suzanne, Lohmann Ebba, Thobois Stéphane, De Michele Giuseppe, Borg Michel, Agid Yves, Dürr Alexandra, Brice Alexis

Abstract excerpt

Parkinson's disease is a frequent disorder caused primarily by the loss of dopaminergic neurons of the substantia nigra. Mutations in the PTEN-induced kinase (PINK1) gene, in addition to those in parkin and DJ-1, have been found in families with recessive early-onset Parkinson's disease. We screened for parkin and PINK1 mutations in a panel of 177 autosomal recessive Parkinson's disease families with ages at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Parkinsonian Disorders

Share to Pedigree

Share to Protein Kinases

Share to Sequence Alignment

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 16401616
DOI: 10.1093/brain/awl005

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa.PMID 16401616Read ↗

Analysis of the PINK1 Gene in a Large Cohort of Cases With Parkinson DiseaseSemantic proximity Read ↗

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease.Semantic proximity Read ↗

Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism.Semantic proximity Read ↗

PINK1 mutations in sporadic early-onset Parkinson's disease.Semantic proximity Read ↗

Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.Semantic proximity Read ↗

Mutation analysis of PINK1 gene in patients with early-onset Parkinsonism.Semantic proximity Read ↗

Novel PINK1 mutations in early-onset parkinsonism.Semantic proximity Read ↗

Rethinking 'rare' PINK1 Parkinson's disease: A meta-analysis of geographical prevalence, phenotypic diversity, and α-synuclein pathology.Semantic proximity Read ↗

Genetic association study of PINK1 coding polymorphisms in Parkinson's disease.Semantic proximity Read ↗

Late onset sporadic Parkinson's disease caused by PINK1 mutations: clinical and functional study.Semantic proximity Read ↗

Autosomal recessive parkinsonism.Semantic proximity Read ↗

Homozygous PINK1 C-terminus mutation causing early-onset parkinsonism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.