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The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP)

29 Nov 2006

Abstract excerpt

The Wiskott-Aldrich syndrome protein (WASP) is a key molecule for transduction of extracellular signals that induce a variety of critical biological events involving actin cytoskeleton rearrangement. Among the cellular partners of WASP, the Wiskott-Aldrich syndrome protein-interacting protein (WIP) has been speculated to play a critical role in the pathophysiology of Wiskott-Aldrich syndrome since WASP mutation...

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PMID: 17205972
DOI: 10.1093/intimm/dxl135

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Related research

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The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP)PMID 17205972Read ↗

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cellsSemantic proximity Read ↗

WIP is a chaperone for Wiskott–Aldrich syndrome protein (WASP)Semantic proximity Read ↗

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP.Semantic proximity Read ↗

WIP null mice display a progressive immunological disorder that resembles Wiskott–Aldrich syndromeSemantic proximity Read ↗

Requirement for a Complex of Wiskott-Aldrich Syndrome Protein (WASP) with WASP Interacting Protein in Podosome Formation in MacrophagesSemantic proximity Read ↗

X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP)Semantic proximity Read ↗

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeletonSemantic proximity Read ↗

WIP is critical for T cell responsiveness to IL-2Semantic proximity Read ↗

FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich SyndromeSemantic proximity Read ↗

New Structural Insights into Formation of the Key Actin Regulating WIP-WASp Complex Determined by NMR and Molecular Imaging.Semantic proximity Read ↗

Retrovirus-mediated WASP gene transfer corrects defective actin polymerization in B cell lines from Wiskott-Aldrich syndrome patients carrying 'null' mutations.Semantic proximity Read ↗

The role of Wiskott-Aldrich Syndrome protein in activation and function of human T cellsSemantic proximity Read ↗

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