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Article

Prevention of rejection of allogeneic endothelial cells in a biohybrid lung by silencing HLA-class I expression.

Biomaterials - 1 Sept 2014

Wiegmann Bettina, Figueiredo Constança, Gras Christiane, Pflaum Michael, Schmeckebier Sabrina, Korossis Sotirios, Haverich Axel, Blasczyk Rainer

Abstract excerpt

Variability in Human Leukocyte Antigens (HLA) remains a hurdle to the application of allogeneic cellular products. Due to insufficient autologous endothelial cell harvesting for the biohybrid lung, allogeneic human cord blood derived endothelial cells (HCBEC) were used for the endothelialization of poly-4-methyl-1-pentene (PMP) gas exchange membranes. Therefore, HLA class I expression was silenced stably in...

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Identifiers

PMID: 24961166
DOI: 10.1016/j.biomaterials.2014.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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