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Article

Fgd5 identifies hematopoietic stem cells in the murine bone marrow.

The Journal of experimental medicine - 30 Jun 2014

Gazit Roi, Mandal Pankaj K, Ebina Wataru, Ben-Zvi Ayal, Nombela-Arrieta César, Silberstein Leslie E, Rossi Derrick J

Abstract excerpt

Hematopoietic stem cells (HSCs) are the best-characterized tissue-specific stem cells, yet experimental study of HSCs remains challenging, as they are exceedingly rare and methods to purify them are cumbersome. Moreover, genetic tools for specifically investigating HSC biology are lacking. To address this we sought to identify genes uniquely expressed in HSCs within the hematopoietic system and to develop a...

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Identifiers

PMID: 24958848
DOI: 10.1084/jem.20130428
PMCID: PMC4076584

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