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Pharmacogenetics of Drug-Induced Birth Defects: The Role of Polymorphisms of Placental Transporter Proteins

1 May 2014

Abstract excerpt

One of the ongoing issues in perinatal medicine is the risk of birth defects associated with maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the exposition of the fetus to the drug. Transporter proteins are known to be involved in the pharmacokinetics of drugs and have an effect on drug level and fetal drug exposure. This condition may subsequently alter the risk of...

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PMID: 24956255
DOI: 10.2217/pgs.14.62

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