Article
Polymorphism of the cystatin C gene in patients with acute coronary syndromes: Results from the PLATelet inhibition and patient Outcomes study.
American heart journal - 1 Jul 2014
Akerblom Axel, Eriksson Niclas, Wallentin Lars, Siegbahn Agneta, Barratt Bryan J, Becker Richard C, Budaj Andrzej, Himmelmann Anders, Husted Steen, Storey Robert F, Johansson Asa, James Stefan K
Abstract excerpt
PURPOSE: Elevated cystatin C concentration is an independent risk factor for cardiovascular (CV) events in patients with acute coronary syndromes. Genetic polymorphisms in CST3 influence cystatin C levels, but their relationship to outcomes is unclear. METHODS: We measured cystatin C concentrations in plasma, obtained within 24 hours of admission, in 16,279 acute coronary syndrome patients from the PLATO trial....
Topics
- Acute Coronary Syndrome
- Aged
- Cystatin C
- DNA
- Female
- Follow-Up Studies
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Middle Aged
- Platelet Aggregation Inhibitors
- Polymorphism, Genetic