Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality.

doi:10.1053/j.ajkd.2013.06.015

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Article

Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jan 2014

O'Seaghdha Conall M, Tin Adrienne, Yang Qiong, Katz Ronit, Liu Yongmei, Harris Tamara, Astor Brad, Coresh Josef, Fox Caroline S, Kao W H Linda, Shlipak Michael G

Abstract excerpt

BACKGROUND: Carriers of the T allele of the single-nucleotide polymorphism rs13038305 tend to have lower cystatin C levels and higher cystatin C-based estimated glomerular filtration rate (eGFRcys). Adjusting for this genetic effect on cystatin C concentrations may improve GFR estimation, reclassify cases of chronic kidney disease (CKD), and strengthen risk estimates for cardiovascular disease (CVD) and...

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PMID: 23932088
DOI: 10.1053/j.ajkd.2013.06.015
PMCID: PMC3872167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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