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Article

Thermodynamic mechanism for the evasion of antibody neutralization in flaviviruses.

Journal of the American Chemical Society - 23 Jul 2014

Maillard Rodrigo A, Liu Tong, Beasley David W C, Barrett Alan D T, Hilser Vincent J, Lee J Ching

Abstract excerpt

Mutations in the epitopes of antigenic proteins can confer viral resistance to antibody-mediated neutralization. However, the fundamental properties that characterize epitope residues and how mutations affect antibody binding to alter virus susceptibility to neutralization remain largely unknown. To address these questions, we used an ensemble-based algorithm to characterize the effects of mutations on the...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dengue Virus

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Source

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Identifiers

PMID: 24950171
DOI: 10.1021/ja503318x
PMCID: PMC4111217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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