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Article

Induction of type I and type III interferons by Borrelia burgdorferi correlates with pathogenesis and requires linear plasmid 36.

PloS one - 1 Jan 2014

Krupna-Gaylord Michelle A, Liveris Dionysios, Love Andrea C, Wormser Gary P, Schwartz Ira, Petzke Mary M

Abstract excerpt

The capacity for Borrelia burgdorferi to cause disseminated infection in humans or mice is associated with the genotype of the infecting strain. The cytokine profiles elicited by B. burgdorferi clinical isolates of different genotype (ribosomal spacer type) groups were assessed in a human PBMC co-incubation model. RST1 isolates, which are more frequently associated with disseminated Lyme disease in humans and...

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Identifiers

PMID: 24945497
DOI: 10.1371/journal.pone.0100174
PMCID: PMC4063763

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TNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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