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Article

Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain.

The Journal of infectious diseases - 15 Sept 2002

Wang Guiqing, Ojaimi Caroline, Wu Hongyan, Saksenberg Victoria, Iyer Radha, Liveris Dionysios, McClain Steve A, Wormser Gary P, Schwartz Ira

Abstract excerpt

The pathogenicity of Borrelia burgdorferi sensu stricto clinical isolates representing 2 distinct ribosomal DNA spacer restriction fragment-length polymorphism genotypes (RSTs) was assessed in a murine model of Lyme disease. B. burgdorferi was recovered from 71.5% and 26.6% of specimens from mice infected with RST1 and RST3 isolates, respectively (P<.0001). The average ankle diameter and histologic scores for...

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Identifiers

PMID: 12198612
DOI: 10.1086/343043
PMCID: PMC2773673

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Source receipt: pubmed, retrieved 7 Sept 2026.

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