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Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4

24 Oct 2012

Abstract excerpt

SLX4, the newly identified Fanconi anemia protein, FANCP, is implicated in repairing DNA damage induced by DNA interstrand cross-linking (ICL) agents, topoisomerase I (TOP1) inhibitors, and in Holliday junction resolution. It interacts with and enhances the activity of XPF-ERCC1, MUS81-EME1, and SLX1 nucleases, but the requirement for the specific nucleases in SLX4 function is unclear. Here, by complementing a...

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PMID: 23093618
DOI: 10.1182/blood-2012-07-441212

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