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Article

An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.

The AAPS journal - 1 Sept 2014

Helms Hans Christian, Hersom Maria, Kuhlmann Louise Borella, Badolo Lasina, Nielsen Carsten Uhd, Brodin Birger

Abstract excerpt

Efflux transporters of the ATP-binding cassette superfamily including breast cancer resistance protein (Bcrp/Abcg2), P-glycoprotein (P-gp/Abcb1) and multidrug resistance-associated proteins (Mrp's/Abcc's) are expressed in the blood-brain barrier (BBB). The aim of this study was to investigate if...

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Identifiers

PMID: 24934296
DOI: 10.1208/s12248-014-9628-1
PMCID: PMC4147044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24934296-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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