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Article

Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.

Sexually transmitted diseases - 1 Jul 2014

Marra Christina M, Sahi Sharon K, Tantalo Lauren C, Ho Emily L, Dunaway Shelia B, Jones Trudy, Hawn Thomas R

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms (SNPs) in toll-like receptors (TLR) 1, 2, and 6 impair cell signaling in response to spirochetal lipoproteins. We investigated whether common SNPs in TLR1, TLR2, or TLR6 were associated with laboratory- or clinically-defined neurosyphilis. METHODS: Polymorphisms in the genes for TLR1 (a T→G mutation at position 1805), TLR2 (a G→A mutation at position 2258), and TLR6 (a...

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Identifiers

PMID: 24922103
DOI: 10.1097/OLQ.0000000000000149
PMCID: PMC4414322

Genes

TLR2
TLR6
TLR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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