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The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals.

Infection and immunity - 15 Dec 2020

Grillová Linda, Musilová Jana, Janečková Klára, Pospíšilová Petra, Kuklová Ivana, Woznicová Vladana, Zákoucká Hana, Šmajs David

Abstract excerpt

Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and...

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PMID: 33077622
DOI: 10.1128/IAI.00503-20
PMCID: PMC7927923

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