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Article

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Sept 2005

Comery Thomas A, Martone Robert L, Aschmies Suzan, Atchison Kevin P, Diamantidis George, Gong Xiaohai, Zhou Hua, Kreft Anthony F, Pangalos Menelas N, Sonnenberg-Reines June, Jacobsen J Steven, Marquis Karen L

Abstract excerpt

Transgenic mice (Tg2576) overexpressing the Swedish mutation of the human amyloid precursor protein display biochemical, pathological, and behavioral markers consistent with many aspects of Alzheimer's disease, including impaired hippocampal function. Impaired, hippocampal-dependent, contextual fear conditioning (CFC) is observed in mice as young as 20 weeks of age. This impairment can be attenuated after...

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Identifiers

PMID: 16192379
DOI: 10.1523/JNEUROSCI.2693-05.2005
PMCID: PMC6725598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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