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Article

Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites.

Cancer research - 1 Mar 2009

Blevins-Primeau Andrea S, Sun Dongxiao, Chen Gang, Sharma Arun K, Gallagher Carla J, Amin Shantu, Lazarus Philip

Abstract excerpt

Tamoxifen (TAM) is a selective estrogen receptor modulator widely used in the prevention and treatment of breast cancer. A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM and endoxifen, is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes. To examine whether polymorphisms in the UGT enzymes responsible for the glucuronidation of active TAM metabolites play an...

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Identifiers

PMID: 19244109
DOI: 10.1158/0008-5472.CAN-08-3708
PMCID: PMC2683344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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