Article
Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night.
Nucleic acids research - 1 Jul 2014
deHaro Dawn, Kines Kristine J, Sokolowski Mark, Dauchy Robert T, Streva Vincent A, Hill Steven M, Hanifin John P, Brainard George C, Blask David E, Belancio Victoria P
Abstract excerpt
Expression of long interspersed element-1 (L1) is upregulated in many human malignancies. L1 can introduce genomic instability via insertional mutagenesis and DNA double-strand breaks, both of which may promote cancer. Light exposure at night, a recently recognized carcinogen, is associated with...
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