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Article

Role of Melatonin in Cancer: Effect on Clock Genes

18 Jan 2023

Abstract excerpt

The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption with aberrant functionality in clock gene expression, resulting in multiple diseases, including cancer. In this context, tumor cells have an altered circadian machinery compared to normal cells, which deregulates the cell...

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PMID: 36768253
DOI: 10.3390/ijms24031919

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