Article

Altered expression of MMP9 and TIMP1 leads to impaired placentation in early onset preeclamptic patients: a case control study

2023-03-14

Abstract excerpt

<h4>Introduction</h4> Matrix metalloproteinases (MMPs) specifically MMP-9 is a key regulator of vascular and uterine spiral artery remodelling and its activity is controlled at multiple levels, including gene transcription, activation of its latent forms and endogenous inhibition by tissue inhibitors of metalloproteinases [TIMPs (specifically TIMP-1)]. Alteration in MMP-9 and TIMP-1 expression may contribute to u...

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Literature Corpus work: 2523b000-e2b3-55bf-bafd-54ff7da30ca9
DOI: 10.1101/2023.03.08.531753

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