Article
Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis.
FEMS immunology and medical microbiology - 1 Apr 2006
Selvaraj Paramasivam, Jawahar Mohideen S, Rajeswari Dhanushkodi N, Alagarasu Kalichamy, Vidyarani Mohankumar, Narayanan Paranji R
Abstract excerpt
Mannose-binding lectin (MBL) plays an important role in innate immunity. Functional mutant homozygotes of the MBL gene affect the serum MBL levels and have been correlated with disease susceptibility. We have studied the regulatory role of variant MBL genotypes on serum MBL level and macrophage phagocytosis with live Mycobacterium tuberculosis, and the lymphoproliferative response to M. tuberculosis culture...
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