mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells.

doi:10.1186/1476-4598-13-144

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mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells.

Molecular cancer - 8 Jun 2014

Smalley Sarah, Chalmers Anthony J, Morley Simon J

Abstract excerpt

BACKGROUND: Glioblastoma multiforme (GBM), the most common and most aggressive type of primary adult brain tumour, responds poorly to conventional treatment. Temozolomide (TMZ) chemotherapy remains the most commonly used treatment, despite a large proportion of tumours displaying TMZ resistance....

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mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells.

Abstract excerpt

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